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產品基本信息

產品編號：C178540

產品名稱：(αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-

產品CAS：

規(guī)格含量：100mg

產品價格：面議

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產品詳細介紹

標準品編號:	C178540
名稱:	(αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid α-ethyl Ester
別名:	Sacubitril methyl ester; 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid
分子式:	C??H??NO?
分子量:	397.46
類別:	Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
應用:	(Î±R,Î³S)-Î³-[(3-Carboxy-1-oxopropyl)amino]-Î±-methyl-[1,1'-biphenyl]-4-pentanoic acid Î±-ethyl Ester is an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
參考文獻	McMurray, J., et al.: N. Eng. J. Med., 371 (2014);

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