Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
Isotope labelled Dabigatran Acyl-β-D-Glucuronide (D100085) is the major metabolite of Dabigatran (D100090) in humans. Four isomeric acylglucuronides of Dabigatran were isolated and purified from urine of dosed rhesus monkeys. NMR analysis confirmed the structures of the four metabolites as the 1-O-acylglucuronide (β anomer) and the 2-O-, 3-O-, and 4-O-acylglucuronides (α and β anomers).
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