N6-Cyclopropyl-d4-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; Abacavir-d4 Related Compound D; Abacavir Stable Isotope
備用CAS:
未標(biāo)記：1443421-69-9
分子式:
C??H??D?ClN??O
分子量:
432.9
類(lèi)別:
Building Blocks; Isotopic Labeled Analogues;
應(yīng)用:
Abacavir-d4 5’-4-Chloro-6-methylpyrimidine-2,5-diamine is deuterium labeled Abacavir 5’-4-Chloro-6-methylpyrimidine-2,5-diamine (A105035), a degradation product of Abacavir Sulfate (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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