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產(chǎn)品基本信息

產(chǎn)品編號：E926745

產(chǎn)品名稱：6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride

產(chǎn)品CAS：1359873-45-2

規(guī)格含量：50mg

產(chǎn)品價格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號:	E926745
名稱:	6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride
別名:	4-(4-(1,3,4-Thiadiazol-2-yl)piperazin-1-yl)-6-ethylthieno[2,3-d]pyrimidine Hydrochloride; MI-nc (hydrochloride);
CAS號:	1359873-45-2
參考CAS:	1359873-35-0
分子式:	C??H??ClN?S?
外觀:	白色至白色固體
熔點:	>188°C (dec.)
分子量:	368.91
儲存:	冰箱保存
溶解度:	DMSO (Slightly), Methanol (Slightly)
種類:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:	6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine is an inhibitor of fusion protein interaction of menin-mixed lineage leukemia (menin-MLL). Menin-MLL inhibitors downregulate the expression of target genes required for MLL fusion protein oncogenic activity and thus effectively reverse MLL fusion protein-mediated leukemic transformation.
參考文獻(xiàn)	Grembecka, J. et al.: Nat. Chem. Biol., 8, 277 (2012);

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