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產(chǎn)品基本信息
產(chǎn)品編號：Z623505
產(chǎn)品名稱：Zoledronic acid
產(chǎn)品CAS：118072-93-8
規(guī)格含量：25mg
產(chǎn)品價(jià)格：面議
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產(chǎn)品詳細(xì)介紹
標(biāo)準(zhǔn)品編號:
Z623505
名稱:
Zoledronic acid
別名:
P,P'-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-phosphonic Acid; [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-phosphonic acid; (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid; 1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene-1,1-bisphosphonic acid; 2-(Imidazol-1-yl)-1-hydroxy-1,1'-ethylidenediphosphonic acid; Aclasta; BPH 91; CGP 42446; Orazol; Reclast; ZOL 446; Zoledronate; Zoledronic acid; Zometa
CAS號:
118072-93-8
分子式:
C?H??N?O?P?
外觀:
白色至白色固體
熔點(diǎn):
>210°C (Subl.)
分子量:
272.09
儲存:
Hygroscopic, 冰箱, under inert atmosphere
溶解度:
Water (Slightly)
穩(wěn)定性:
extremely hygroscopic
類別:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.
參考文獻(xiàn)
Jagdev, S., et al.: Br. J. Cancer, 84, 1126 (2001); Viereck, V., et al.: Biochem. Biophys. Res. Commun., 291, 680-686. Croucher. P., et al.: J. Bone Miner. Res., 2003, 18(3), 482-492.
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