N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid; 4-Aminofolic Acid, 4-Aminopteroyl-L-glutamic Acid, 4-Amino-PGA; NSC 739; USP Methotrexate Related Compound B; Methotrexate EP Impurity B
雜質(zhì):
Methotrexate EP Impurity B
CAS號(hào):
54-62-6
分子式:
C??H??N?O?
狀態(tài)：
Dark Yellow Solid
熔點(diǎn)：
>200°C (dec.)
分子量:
440.41
儲(chǔ)存：
-20°C Freezer
溶解性:
DMF, DMSO
類別:
Standards; Amino Acids; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
Aminopterin (Methotrexate EP Impurity B) is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
危險(xiǎn)品信息:
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
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