Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
4-(3-(4-(Cyclopropanecarbonyl)-3-hydroxypiperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one is an impurity of Olaparib (O514500), a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy. Potent PARP inhibitor.
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