產(chǎn)品基本信息
產(chǎn)品編號：D231270
產(chǎn)品名稱：N-De[2-(methylsulfonyl)ethyl] Lapatinib
產(chǎn)品CAS：697299-82-4
規(guī)格含量：50mg
產(chǎn)品價格：面議
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產(chǎn)品詳細(xì)介紹
標(biāo)準(zhǔn)品編號:
D231270
名稱:
N-De[2-(methylsulfonyl)ethyl] Lapatinib
別名:
6-[5-(Aminomethyl)-2-furanyl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-4-quinazolinamine; [6-(5-Aminomethylfuran-2-yl)quinazolin-4-yl][3-chloro- 4-(3-fluorobenzyloxy)phenyl]amine;
CAS號:
697299-82-4
分子式:
C??H??ClFN?O?
外觀:
Light Yellow to Light Beige Solid
熔點:
>141ºC (dec.)
分子量:
474.91
儲存:
-20°C Freezer, Under inert atmosphere
溶解性:
DMSO (Slightly), Methanol (Slightly, Heated)
種類:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.
參考文獻
He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),
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