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產(chǎn)品基本信息

產(chǎn)品編號(hào)：F401290

產(chǎn)品名稱：(R)-FL-118

產(chǎn)品CAS：151636-76-9

規(guī)格含量：2.5mg

產(chǎn)品價(jià)格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號(hào):	F401290
名稱:	(R)-FL-118
別名:	(R)-7-Ethyl-7-hydroxy-7H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(10H,13H)-dione; 10,11-(Methylenedioxy)-20(R)-camptothecin; (7R)-7-Ethyl-7-hydroxy-10H-1,3-dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione;
CAS號(hào):	151636-76-9
分子式:	C??H??N?O?
分子量:	392.36
種類:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:	(R)-FL-118 is a derivative of Camptothecin (C175150), which is antitumor alkaloid that binds to the DNVIP(LA)topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I, trapping the enzyme in a covalent linkage with DNA.
參考文獻(xiàn)	Potmesil, M., et al.: Cancer Res., 54, 1431 (1994); Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1997); Fan, Y., et al.: J. Med. Chem., 41, 2216 (1998); Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1998); Del Poeta, M., et al.: Antimicrob. Agents Chemother., 43, 2862 (1999);

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