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產(chǎn)品基本信息
產(chǎn)品編號：X746220
產(chǎn)品名稱：XL388
產(chǎn)品CAS：1251156-08-7
規(guī)格含量：5mg
產(chǎn)品價格：面議
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產(chǎn)品詳細介紹
標(biāo)準(zhǔn)品編號:
X746220
名稱:
XL388
別名:
(7-(6-Aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone; [7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone
CAS號:
1251156-08-7
分子式:
C??H??FN?O?S
外觀:
白色至淡黃色固體
熔點:
>188ºC (dec.)
分子量:
455.5
儲存:
Hygroscopic, 冰箱, under inert atmosphere
溶解度:
DMSO (Slightly)
類別:
Research Tools; Enzyme Activators and Inhibitors;
應(yīng)用:
XL388 is a highly potent, orally bioavailable, selective, ATP-competitive mammalian target of rapamycin (mTOR) inhibitor. XL388 has shown significant and dose-dependent antitumor activity in athymic nude mice implanted with human tumor xenografts.
參考文獻
Takeuchi, C.S., et. al.: J Med. Chem., 56, 2218 (2013)
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