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產(chǎn)品基本信息

產(chǎn)品編號(hào)：G797400

產(chǎn)品名稱：GSI-953

產(chǎn)品CAS：769169-27-9

規(guī)格含量：10mg

產(chǎn)品價(jià)格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號(hào):	G797400
名稱:	GSI-953
別名:	5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide; Begacestat; GSI 953;
CAS號(hào):	769169-27-9
分子式:	C?H?ClF?NO?S?
外觀:	白色固體
熔點(diǎn):	153-155°C
分子量:	391.74
儲(chǔ)存:	-20°C Freezer
溶解度:	DMSO, Methanol
種類:	Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:	Begacestat (GSI-953) is a selective β-secretase inhibitor that selectively inhibits cleavage of APP over Notch. GSI-953 is used for treating diseases such as cancer in relation to prevention of intestinal secretory metaplasia.
參考文獻(xiàn)	van Es., et al.: Nature, 435, 959 (2005), Morohashi., et al.: J. Biol. Chem., 281, 1467 (2006), O'Neil., et al.: Neoplasia, 107, 781 (2006), Mayer, et al.: J. Med. Chem., 51, 7348 (2008), Martone, et al.: J. Pharmacol. Exp. Ther., 331, 598 (2009),

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