6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one compound with 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one;
CAS號(hào):
1374996-60-7
分子式:
C??H?N?O •C??H?N?O
分子量:
224.1822418
種類:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells.
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