[1R-(exo,exo)]-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester; O 371;
CAS號(hào):
130342-80-2
分子式:
C??H??ClNO?
外觀:
白色固體
熔點(diǎn):
116-119°C
分子量:
293.79
儲(chǔ)存:
Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度:
Chloroform (Slightly), Methanol (Sparingly)
穩(wěn)定性:
Hygroscopic
類別:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
RTI-COC 31 is a potent phenyltropane cocaine analog which exhibits inhibitory interactions with serotonergic neurons. Also, it is an intermediate used in the synthesis of RTI-113 (R701110), which is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence.
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