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產(chǎn)品基本信息

產(chǎn)品編號(hào)：B286820

產(chǎn)品名稱：7-Benzyloxy Granisetron

產(chǎn)品CAS：133841-14-2

規(guī)格含量：10mg

產(chǎn)品價(jià)格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號(hào):	B286820
名稱:	7-Benzyloxy Granisetron
別名:	endo-1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-7-(phenylmethoxy)-1H-indazole-3-carboxamide; 7-(Benzyloxy)-1-methyl-N-((1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide
CAS號(hào):	133841-14-2
分子式:	C??H??N?O?
分子量:	418.53
類別:	Research Tools; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:	7-Benzyloxy Granisetron is an intermediate in the synthesis of 7-Hydroxy Granisetron (H942675), a metabolite of Granisetron (G780000), a specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptor.
文獻(xiàn)	Bloomer, J., et al.: Brit. J. Clin. Pharmacol., 38, 557 (1994); Vernekar, S.,e t al.: J. Med. Chem., 53, 2324 (2010); Kilpatrick, G.J., et al.: Nature, 330, 746 (1987); Durig, T., et al.: J. Pharm. Sci., 86, 1092 (1997); Yuasa, H., et al.: Chem. Pharm. Bull., 44, 1361 (1996)

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