產(chǎn)品基本信息
產(chǎn)品編號：B692460
產(chǎn)品名稱：2'-O-(tert-Butyldimethylsilyl)paclitaxel 7-O-triflate
產(chǎn)品CAS：165065-01-0
規(guī)格含量：50mg
產(chǎn)品價格：面議
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產(chǎn)品詳細(xì)介紹
標(biāo)準(zhǔn)品編號:
B692460
名稱:
2'-O-(tert-Butyldimethylsilyl)paclitaxel 7-O-triflate
別名:
2'-O-(tert-Butyldimethylsilyl)-7-O-(trifluoromethanesulfonyl)paclitaxel; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-Benzamido-2-((tert-butyldimethylsilyl)oxy)-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((trifluoromethyl)sulfonyl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyl Diacetate; [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-benzenepropanoic Acid 6,12b-bis(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-[[(trifluoromethyl)sulfonyl]oxy]-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester
CAS號:
165065-01-0
分子式:
C??H??F?NO??SSi
分子量:
1100.23
類別:
Building Blocks; Miscellaneous;
應(yīng)用:
2'-O-(tert-Butyldimethylsilyl)paclitaxel 7-O-triflate is an intermediate in the synthesis of 6α-Hydroxy Paclitaxel (H948890), the major human metabolite of Paclitaxel (P132500), an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
參考文獻(xiàn)
Walle, T., et al.: Biochem. Pharm., 46, 1661 (1993); Kumar, G., et al.: Drug Metab. Dispos., 22, 177 (1994); Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984); Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995); Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002); Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004)
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