Standards; Molecular Biology; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites; Controlled Substances and Drugs of Abuse for Forensic Testing; Opiates;
應用:
N-Methyl Naltrexone Sulfate is a metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX; M320350), a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone (M320350) is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance.
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