Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應用:
ABT 594 Hydrochloride selective α4β2 nAChR agonist (EC50 = 140 nM for human α4β2 nAChRs, in vitro). Exhibits >900-fold selectivity for α4β2 nAChRs over other neurotransmitter receptors. Displays analgesic properties in various animal models of pain. Potentiates gabapentin mediated analgesia. Also demonstrates cognitive enhancement effects in rodent model of attention deficit.
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