產(chǎn)品基本信息
產(chǎn)品編號：D230750
產(chǎn)品名稱：Demecolceine
產(chǎn)品CAS：518-11-6
規(guī)格含量：50mg
產(chǎn)品價格：面議
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產(chǎn)品詳細介紹
標(biāo)準(zhǔn)品編號:
D230750
名稱:
Demecolceine
別名:
(7S)-6,7-Dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one; 7-Deacetamido-7-(methylamino)colchiceine; N-Desacetyl-N-methylcolchiceine; NSC 36559;
CAS號:
518-11-6
分子式:
C??H??NO?
外觀:
Yellow Solid
熔點:
120-122°C
分子量:
357.4
儲存:
Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解性:
Chloroform (Slightly), Methanol (Slightly, Heated)
種類:
Standards; Enzyme Activators and Inhibitors;
應(yīng)用:
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
參考文獻
Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),
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