Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應用:
1-?[4-?[[(3R,?4R)?-?1-?Acetyl-?4-?methyl-?3-?piperidinyl]?methylamino]?-?7H-?pyrrolo[2,?3-?d]?pyrimidin-?7-?yl]?ehtanone is an intermediate in the synthesis of Tofacitinib Impurity Z (T528030), which is an impurity of Tofacitinib (T528000), an enantiopure stereoisomer of the drug, Janus kinase 3 (Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases.
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