Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
應(yīng)用:
B I09, is a novel chromenone-based covalent inhibitors of IIRE-1 RNase. It Inhibits IRE-1/XBP1 pathway, and thus growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.
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