 ?您的位置：對(duì)照品 > 標(biāo)準(zhǔn)品 > 分析標(biāo)準(zhǔn)品 > |
|
|
|
| 產(chǎn)品基本信息 |
|
| 產(chǎn)品編號(hào)：M220435 |
| 產(chǎn)品名稱：Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid |
| 產(chǎn)品CAS：419563-23-8 |
| 規(guī)格含量：5g |
| 產(chǎn)品價(jià)格：面議 |
| 聯(lián)系我們: |
 |
|
 |
|
|
| 產(chǎn)品詳細(xì)介紹 |
| 標(biāo)準(zhǔn)品編號(hào): |
M220435 |
| 名稱: |
Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid |
| CAS號(hào): |
419563-23-8 |
| 參考CAS號(hào): |
352226-74-5 |
| 分子式: |
C?H??NO? • C ?H?O? |
| 分子量: |
141.1715009 |
| 種類: |
Building Blocks; Miscellaneous; |
| 應(yīng)用: |
Methyl (1R,4S)-4-Amino-2-cyclopentene-1-carboxylate (2S,3S)-2,3-Dihydroxybutanedioic Acid is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| 參考文獻(xiàn) |
|
|
|
|
|
|
