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產(chǎn)品基本信息

產(chǎn)品編號(hào)：T338202

產(chǎn)品名稱：TH-302-d8

產(chǎn)品CAS：918632-75-4

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產(chǎn)品價(jià)格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號(hào):	T338202
名稱:	TH-302-d8
別名:	N,N'-Bis(2-bromoethyl)phosphorodiamidic Acid-d8 (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl Ester;
CAS號(hào):	918632-75-4
參考CAS號(hào):	Unlabelled: 918633-87-1
分子式:	C?H?D?Br?N?O?P
分子量:	457.09
類別:	Building Blocks; Isotopic Labeled Analogues;
應(yīng)用:	TH-302-d8 is the isotope labelled analog of TH-302 (T338200), a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard. Studies have shown that TH-302 treatment exhibited hypoxia-selective cytotoxicity and DNA damage in human cancer cell.
參考文獻(xiàn)	Meng, F. et al.: Mol. Cancer Ther., 11, 740 (2012); Liu, Q. et al.: Cancer Chemother. Pharmacol., 69, 1487 (2012); Sun, J.D. et al.: Clin. Cancer Res., 18, 758 (2012);

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