5,?6-?Dihydro-?4-?methyl-?6-?(2,?6,?6-?trimethyl-?1-?cyclohexen-?1-?yl)?-2H-?pyran-?2-?one is an intermediate in synthesizing 9-cis,13-cis-Retinoic Acid (R245015), an endogenous retinoid that induces liver fibrosis via the activation of latent transforming growth factor-β. A major plasma metabolite of 9-cis Retinoic Acid (R245000).