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產(chǎn)品基本信息

產(chǎn)品編號(hào)：D474165

產(chǎn)品名稱：(1R,?2S)?-2-?[3-?[(1E)?-?2-?[4-?[[(2R,?6S)?-?2,?6-?Dimethyl-?4-?

產(chǎn)品CAS：1338806-73-7

規(guī)格含量：2.5mg

產(chǎn)品價(jià)格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號(hào):	D474165
名稱:	(1R,?2S)?-2-?[3-?[(1E)?-?2-?[4-?[[(2R,?6S)?-?2,?6-?Dimethyl-?4-?morpholinyl]?methyl]?phenyl]?ethenyl]?-?1H-?indazol-?6-?yl]?-?5'-?methoxy-?spiro[cyclopropane-?1,?3'-?[3H]?indol]?-?2'(1'H)?-?one
CAS號(hào):	1338806-73-7
分子式:	C??H??N?O?
分子量:	534.65
種類:	Standards; Enzyme Activators and Inhibitors;
應(yīng)用:	(1R,?2S)?-2-?[3-?[(1E)?-?2-?[4-?[[(2R,?6S)?-?2,?6-?Dimethyl-?4-?morpholinyl]?methyl]?phenyl]?ethenyl]?-?1H-?indazol-?6-?yl]?-?5'-?methoxy-?spiro[cyclopropane-?1,?3'-?[3H]?indol]?-?2'(1'H)?-?one selectively inhibits polo-like kinase 4 (PLK4), which is a serine/threonine protein kinase that regulates centriole duplication during the cell cycle. PLK4 is a therapeutic target for various cancers.
參考文獻(xiàn)	Sredni, S. T., et al.: Pediatr Blood Cancer. e26551 (2017); Sampson, P. B., et al.: J Med Chem. 58, 147 (2015)

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