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產(chǎn)品基本信息

產(chǎn)品編號：L486640

產(chǎn)品名稱：LY 311727

產(chǎn)品CAS：164083-84-5

規(guī)格含量：10mg

產(chǎn)品價格：面議

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產(chǎn)品詳細介紹

標準品編號:	L486640
名稱:	LY 311727
別名:	P-[3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]phosphonic Acid; [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]phosphonic Acid; [3-[[3-(Amidomethyl)-2-ethyl-1-(phenylmethyl)indol-5-yl]oxy]propyl]phosphonic Acid
CAS號:	164083-84-5
分子式:	C??H??N?O?P
分子量:	430.43
種類:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
應用:	LY 311727 is an inhibitor of secretory phospholipase A2 (sPLA2) and can be used to block Pseudomonas aeruginosa cytotoxicity. It can also attenuate VEGF-mediated platelet-activating factor (PAF) synthesis in HUVEC and BAEC cells.
參考文獻	Phillips, R., et al.: J. Biol. Chem., 278, 41326 (2003); Buitrago-Rey, R., et al.: J. Antimicrob. Chemoth., 49, 871 (2002); Schevitz, R.W., et al.: Nat. Struct. Biol., 2, 458 (1995); Fleisch, J.H. et al.: J. Pharmacol. Exp. Ther., 278, 252 (1996); Bridonneau, P., et al.: J. Med. Chem., 41, 778 (1998); Bidgood, M.J. et al.: J. Immunol., 165, 2790 (2000); Bernatchez, P.N., et al.: Br. J. Pharmacol., 134, 197 (2001)

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