P-[[(2S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl]ester Triphosphate TEA Salt
備用CAS:
Free acid: 137820-58-7
分子式:
C??H??N?O??P? • xC ?H??N
狀態(tài)：
灰白色至淺褐色固體
熔點(diǎn)：
>104C (dec.)
分子量:
526.2710119
儲(chǔ)存：
Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解性:
Methanol (Slightly), Water (Slightly)
類別:
Research Tools; Molecular Biology; Enzyme Activators and Inhibitors;
應(yīng)用:
Abacavir Triphosphate TEA Salt, is a metabolite of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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