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產(chǎn)品基本信息

產(chǎn)品編號(hào)：D487420

產(chǎn)品名稱(chēng)：N-[(1S)-1-[[(1R,3S,4S)-3-[6-[9,9-Difluoro-7-[2-[(6S)-5-formyl-5-azaspiro[2.4]hept-6-yl]-1H

產(chǎn)品CAS：2040487-30-5

規(guī)格含量：10mg

產(chǎn)品價(jià)格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號(hào):	D487420
名稱(chēng):	N-[(1S)-1-[[(1R,3S,4S)-3-[6-[9,9-Difluoro-7-[2-[(6S)-5-formyl-5-azaspiro[2.4]hept-6-yl]-1H-imidazol-5-yl]-9H-fluoren-2-yl]-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]hept-2-yl]carbonyl]-2-methylpropyl]-, methyl ester carbamic acid
CAS號(hào):	2040487-30-5
分子式:	C??H??F?N?O?
分子量:	759.84
種類(lèi):	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:	N-[(1S)-1-[[(1R,3S,4S)-3-[6-[9,9-Difluoro-7-[2-[(6S)-5-formyl-5-azaspiro[2.4]hept-6-yl]-1H-imidazol-5-yl]-9H-fluoren-2-yl]-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]hept-2-yl]carbonyl]-2-methylpropyl]-, methyl ester carbamic acid is an impurity of Ledipasvir (L320100), which is most commonly used in combination with sofosbuvir for treatment in chronic hepatitis C genotype 1 patients. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.
參考文獻(xiàn)	Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)

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