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產(chǎn)品基本信息

產(chǎn)品編號：N388752

產(chǎn)品名稱：trans-Ned-19-d8

產(chǎn)品CAS：

規(guī)格含量：10mg

產(chǎn)品價(jià)格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號:	N388752
名稱:	trans-Ned-19-d8
別名:	(1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-(piperazinyl-d8)]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylic Acid;
參考CAS號:	類似: 1137263-70-7 (for relative stereochem)
分子式:	C??H??D?FN?O?
分子量:	522.64
種類:	Research Tools; Isotopic Labeled Analogues; Molecular Biology; Enzyme Activators and Inhibitors; Fluorescent Reagents; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:	Labelled trans-Ned-19, a cell permeable and potent nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. trans-Ned-19 inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM) and also inhibits [32P]NAADP binding (IC50 = 0.4 nM). trans-Ned-19 can be used as a chemical proble since it fluorescentey labels NAADP receptors in intact cells.
參考文獻(xiàn)	Rosen, D. et al.: J. Biol. Chem., 284, 34930 (2009); Naylor, E. et al.: Nat. Chem. Biol., 5, 220 (2009); Thai, T.L. et al.: Am. J. Physiol. Renal Physiol., 297, F510 (2009);

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