產品基本信息
產品編號：I268650
產品名稱：IMD 0354
產品CAS：978-62-1
規(guī)格含量：25mg
產品價格：面議
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產品詳細介紹
標準品編號:
I268650
名稱:
IMD 0354
別名:
N-(3,5-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxy-benzamide; 5-Chloro-α,α,α,α',α',α'-hexafluoro-3',5'-salicyloxylidide N-(3,5-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide
CAS號:
978-62-1
分子式:
C??H?ClF?NO?
外觀:
白色固體
熔點:
178-180°C
分子量:
383.67
儲存:
-20°C Freezer
溶解度:
DMSO (Slightly), Methanol (Slightly)
種類:
Research Tools; Enzyme Activators and Inhibitors;
應用:
IMD 0354 is an inhibitor of IKK β (IKK-2) and blocks Iκβα phosphorylation in the NF-κB pathway. IMD 0354 might also have therapeutic efficacy in the treatment of human mesothelioma.
參考文獻
Nishikawa, S., et al.: Cancer Med., 3, 416 (2014); Tanka., A., et al.: Blood, 105, 2324 (2005); Sugita. A., et al.: Int. Arch. Allergy Immunol, 148, 186 (2009); Kamon, J.M., et al.:Biochem., Biophys, Res. Commun,, 323, 242 (2004); Onai, et al.: Cardiovasc. Res., 63, 51 (2004)
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