Abacavir - In House Impurity; (1R,4R)-rel-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Monohydrochloride; Abacavir EP Impurity D
雜質(zhì):
Abacavir EP impurity D
CAS號(hào):
267668-71-3
備用CAS:
free base: 783292-37-5
分子式:
C??H??ClN?O
分子量:
322.79
類別:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
(1R,​4R)​-​rel-4-​[2-Amino-​6-​(cyclopropylamino)​-​9H-​purin-​9-​yl]​-​2-​cyclopentene-​1-​methanol Hydrochloride (Abacavir - In House Impurity) is an impurity of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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