1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine; 6-Amino-4-methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyrimido[4,5-c]pyridazine; API 2; NSC 154020; TCN;
CAS號(hào):
35943-35-2
分子式:
C??H??N?O?
外觀:
白色至淡黃色固體
熔點(diǎn):
211-214°C (dec.)
分子量:
320.3
儲(chǔ)存:
-20?C Freezer
溶解度:
DMSO, Methanol (Slightly, Heated)
類別:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
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