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產(chǎn)品基本信息

產(chǎn)品編號：L178790

產(chǎn)品名稱：LB 42708

產(chǎn)品CAS：226929-39-1

規(guī)格含量：5mg

產(chǎn)品價格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號:	L178790
名稱:	LB 42708
別名:	4-[[1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]carbonyl]morpholine; [1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinylmethanone; (1-((1-(4-Bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone
CAS號:	226929-39-1
分子式:	C??H??BrN?O?
外觀:	白色固體
熔點(diǎn):	165-169ºC
分子量:	555.46
儲存:	-20°C Freezer
溶解度:	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
種類:	Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:	LB 42708 is a selective nonpeptidic Farnesyltransferase (FTase) inhibitor.LB42708 suppresses tumor growth and tumor angiogenesis in both xenograft tumor models of Ras-mutated HCT116 cells and its wild-type Caco-2 cells, indicating its potential application in the treatment of both Ras-mutated and wild type tumors.
參考文獻(xiàn)	Kim, C., et. al.: Mol. Pharmacol., 78, 142 (2010)

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