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產(chǎn)品基本信息

產(chǎn)品編號：R072900

產(chǎn)品名稱：RAF 265

產(chǎn)品CAS：927880-90-8

規(guī)格含量：5mg

產(chǎn)品價格：面議

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產(chǎn)品詳細介紹

標準品編號:	R072900
名稱:	RAF 265
別名:	CHIR 265; 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine
CAS號:	927880-90-8
分子式:	C??H??F?N?O
分子量:	518.41
類別:	Research Tools;
應用:	RAF 265 is a multikinase inhibitor that has displayed BRAF inhibiting activity in clinical trials. It could be used in the treatment of a subpopulation of human melanoma tumors. Has cytotoxic effect of on MDVIP(LA)MB-231 cells. RAF265 when used with BEZ-235 inhibited ERK, PI3K signaling that reduced growth, proliferation and development of drug resistance in human thyroid cancer cells.
參考文獻	Su, Y. et al.: Clin. Cancer. Res., 18, 2184 (2012); Zambon, A. et al.: Bioorg. Med. Chem. Lett., 22, 789 (2012); Dittmer, A. et al.: Int. J. Oncol., 39, 689 (2011); Jin, N. et al.: Clin. Cancer. Res., 17, 6482 (2011)

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