Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
N-Des(4'-chloro-3,3,6-trimethyl-2,3,4,5-tetrahydro-1,1'-biphenyl) Venetoclax is a minor metabolite (dog and mouse) of ABT 199 (A112430), which is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
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