[1S(2S,3S)]-5-Deoxy-1-C-[7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-lyxo-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose; Mithramycin; A 2371; Antibiotic LA 7017; Aureolic Acid; Mithracin; Mitramycin; NSC 24559; PA 144; Plicamycin; Plicatomycin;
CAS號(hào):
18378-89-7
分子式:
C??H??O??
外觀:
Yellow Solid
熔點(diǎn):
>173ºC (dec.)
分子量:
1085.15
儲(chǔ)存:
-20?C Freezer, Under Inert Atmosphere
溶解度:
DMSO (Slightly), Methanol (Slightly)
種類(lèi):
Standards; Others; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics; Carbohydrates and Oligosaccharides;
應(yīng)用:
Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Mithramycin A inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.
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