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產(chǎn)品基本信息

產(chǎn)品編號：D297085

產(chǎn)品名稱：3’-Desnitro-3’-amino ABT 199

產(chǎn)品CAS：

規(guī)格含量：10mg

產(chǎn)品價格：面議

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產(chǎn)品詳細介紹

標準品編號:	D297085
名稱:	3’-Desnitro-3’-amino ABT 199
別名:	2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-N-((3-amino-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzamide; Venetoclax Metabolite M30;
分子式:	C??H??ClN?O?S
分子量:	838.46
種類:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
應用:	3’-Desnitro-3’-amino ABT 199 can be obtained from ABT 199 (A112430) which is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.
參考文獻	Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);

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