Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites; Nicotine Derivatives and Metabolites;
應(yīng)用:
The labelled analogue of a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
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