3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide; AP 24534; Iclusig
CAS號:
943319-70-8
分子式:
C??H??F?N?O
外觀:
白色至Pale Beige Solid
熔點:
>175°C (dec.)
分子量:
532.56
儲存:
Amber Vial, 冰箱, Under inert atmosphere
溶解度:
DMSO (Slightly), Methanol (Slightly)
類別:
Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
應用:
Ponatinib is a tyrosine kinase inhibitors (TKI) and used to treat chronic myeloid leukemia (CML) (1,2,3). Ponatinib is also used in combination with other drugs, such as forskolin, to combat TKI resistance in patient with CML (3), targeted drug in small-cell lung cancer. Potent FAK inhibitor. FGFR/VEGFR/Bcr-Abl inhibitor
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