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產(chǎn)品基本信息

產(chǎn)品編號(hào)：G797415

產(chǎn)品名稱：GSK 5072 Dihydrochloride

產(chǎn)品CAS：

規(guī)格含量：100mg

產(chǎn)品價(jià)格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號(hào):	G797415
名稱:	GSK 5072 Dihydrochloride
別名:	5-(((4-Chlorobenzyl)(pyridin-3-ylmethyl)amino)methyl)thiophene-2-carbonitrile Dihydrochloride; 5-[[[(4-Chlorophenyl)methyl](3-pyridinylmethyl)amino]methyl]-2-thiophenecarbonitrile Dihydrochloride;
參考CAS號(hào):	Free Base: 1438071-23-8
分子式:	C??H??ClN?S • 2(HCl)
外觀:	白色至淡黃色固體
熔點(diǎn):	>137ºC (dec.)
分子量:	353.8723646
儲(chǔ)存:	Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度:	DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
種類:	Research Tools; Molecular Biology;
應(yīng)用:	GSK 5072 Dihydrochloride is an analogue of GSK 4112 (G797700) which is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.
參考文獻(xiàn)	Grant, D. et al.: ACS Chem. Biol., 5, 925 (2010); Kojetin, D. et al.: ACS Chem. Biol., 6, 131 (2011);

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