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產(chǎn)品基本信息

產(chǎn)品編號：D126860

產(chǎn)品名稱：3,17-Diiodoandrosta-3,5,16-triene

產(chǎn)品CAS：1268610-38-3

規(guī)格含量：25mg

產(chǎn)品價格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號:	D126860
名稱:	3,17-Diiodoandrosta-3,5,16-triene
別名:	(8R,9S,10R,13S,14S)-3,17-Diiodo-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthrene; 3,17-Diiodo-androst-3,5,16-triene
CAS號:	1268610-38-3
分子式:	C??H??I?
分子量:	506.2
種類:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:	3,17-Diiodoandrosta-3,5,16-triene is used in the synthesis of 3,17-Dicarboxamido-androst-3,5,16-triene via palladium-catalyzed aminocarbonylation. It is an Abiraterone 3-iodine impurity. Abiraterone is a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
參考文獻(xiàn)	Acs, Peter., et al.: Steroids, 76, 280(2011); Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389 (2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005);

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