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產(chǎn)品基本信息

產(chǎn)品編號(hào)：D447380

產(chǎn)品名稱：5,6-Dihydroabiraterone

產(chǎn)品CAS：219843-75-1

規(guī)格含量：5mg

產(chǎn)品價(jià)格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號(hào):	D447380
名稱:	5,6-Dihydroabiraterone
別名:	(3S,5S,8R,9S,10S,13S,14S)-10,13-Dimethyl-17-(pyridin-3-yl)-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol; (3β,5α)-17-(3-Pyridinyl)-androst-16-en-3-ol;
CAS號(hào):	219843-75-1
分子式:	C??H??NO
分子量:	351.52
種類:	Standards; Pharmaceutical/API Drug Impurities/Metabolites; Steroids;
應(yīng)用:	5,6-Dihydroabiraterone is analog or impurity of Abiraterone (A108490) drug, which is a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17). Abiraterone blocks androgen synthesis and prolongs survival in patients with castration-resistant prostate cancer. It is a potential drug for the treatment of androgen-dependent prostate cancer.
參考文獻(xiàn)	Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005); Jarman, M., et al.: J. Med. Chem., 41, 5375 (1998); Li, Z., et al.: Nature, 533, 547 (2016);

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