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產(chǎn)品基本信息

產(chǎn)品編號：D453658

產(chǎn)品名稱：6,8-Dihydro-7H-pyrrolo[2,3-g]benzothiazol-7-one

產(chǎn)品CAS：222036-27-3

規(guī)格含量：25mg

產(chǎn)品價(jià)格：面議

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產(chǎn)品詳細(xì)介紹

標(biāo)準(zhǔn)品編號:	D453658
名稱:	6,8-Dihydro-7H-pyrrolo[2,3-g]benzothiazol-7-one
別名:	6H-Thiazolo[5,4-e]indol-7(8H)-one
CAS號:	222036-27-3
分子式:	C?H?N?OS
外觀:	Beige Solid
分子量:	190.22
溶解性:	DIchloromethane + Methanol; Methanol
種類:	Standards; Miscellaneous;
應(yīng)用:	6,8-Dihydro-7H-pyrrolo[2,3-g]benzothiazol-7-one is an intermediate in synthesizing Imidazolo-oxindole PKR inhibitor C16 (PKR Inhibitor) (P572500). It is a drug which acts as a selective inhibitor of the enzyme double-stranded RNVIP(LA)dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function in vivo and has neuroprotective and nootropic effects in animal studies.
參考文獻(xiàn)	Jammi, N., et al.: Biochem. Biophys. Res. Commun., 308, 50 (2003); Ingrand, S., et al.: Neurosci. Lett., 409, 192 (2006); Chen, H., et al.: Eur. J. Neurosci., 28, 2003 (2008); Couturier, J., et al.: J. Biol. Chem., 285, 1272 (2010)

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