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| 產(chǎn)品基本信息 |
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| 產(chǎn)品編號：A596515 |
| 產(chǎn)品名稱：(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride |
| 產(chǎn)品CAS：426226-35-9 |
| 規(guī)格含量：10g |
| 產(chǎn)品價格：面議 |
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| 產(chǎn)品詳細介紹 |
| 標準品編號: |
A596515 |
| 名稱: |
(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride |
| 別名: |
Methyl (1R,4S)-4-Aminocyclopent-2-ene-1-carboxylate Hydrochloride |
| CAS號: |
426226-35-9 |
| 備用CAS: |
352226-74-5 |
| 分子式: |
C?H??NO? • HCl |
| 分子量: |
141.173646 |
| 類別: |
Building Blocks; Miscellaneous; |
| 應用: |
(1R,4S)-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride is an intermediate used in the synthesis of ent-Abacavir (A105015), which is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
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