Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
N-​[4-​[[(5R)​-​5-​(benzoyloxy)​-​7-​chloro-​2,​3,​4,​5-​tetrahydro-​1H-​1-​benzazepin-​1-​yl]​carbonyl]​-​3-​methylphenyl]​-​2-​methylbenzamide is an intermediate in the synthesis of (R)-(+)-Tolvaptan (T536640), which is an enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
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