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產品基本信息
產品編號：L465880
產品名稱：Linaclotide
產品CAS：851199-59-2
規(guī)格含量：100mg
產品價格：面議
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產品詳細介紹
標準品編號:
L465880
名稱:
Linaclotide
別名:
L-Cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine Cyclic (1→6),(2→10),(5→13)-Tris(disulfide); 11: PN: WO2008151257 SEQID: 55 claimed protein; 13: PN: WO2008151257 SEQID: 57 Claimed Protein; 2074: PN: US20090062207 SEQID: 3 Claimed Protein; 40: PN: WO2010065751 SEQID: 55 Claimed Protein; 42: PN: WO2010065751 SEQID: 57 claimed protein; 55: PN: US20100152118 SEQID: 55 Claimed Protein; 55: PN: WO2011069038 SEQID: 55 Claimed Sequence; 55: PN: WO2012037380 SEQID: 55 Unclaimed Protein; 57: PN: WO2011069038 SEQID: 57 Claimed Sequence; 57: PN: WO2012037380 SEQID: 57 Claimed Protein;
CAS號:
851199-59-2
參考CAS號:
851199-60-5
分子式:
C??H??N??O??S?
外觀:
白色固體
熔點:
231-235°C (dec.)
分子量:
1526.74
儲存:
Hygroscopic, 冰箱, under inert atmosphere
溶解度:
DMSO (Slightly, Heated), Methanol ((Slightly, Heated)), Water (Slightly, Heated)
種類:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應用:
Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
參考文獻
Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);
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