超氧化物歧化酶 來源于牛紅細(xì)胞, ≥1,400 units/mg dry weight
Product Name： Superoxide Dismutase from bovine erythrocytes
別名:SOD;超氧化物;超氧化物氧化還原酶
CAS號:9054-89-1
介紹： Superoxide dismutase (SOD) catalyzes the removal of the O2- free radical. The enzyme protects oxygen-metabolizing cells against harmful effects of superoxide free-radicals. Superoxide dismutase is inactivated by H2O2. It consists of two subunits of identical molecular weight joined by a disulfide bond. The molecular weight is 32,500 daltons, and there are two Cu(II) and two Zn(II) atoms per molecule. The isoelectric point of the enzyme is 4.95.
用途： Superoxide dismutase from bovine erythrocytes has been used in a study to assess a kinetic model of radiation-induced inactivation of superoxide dismutase in nitrous oxide-saturated solutions. Superoxide dismutase from bovine erythrocytes has also been used in a study to investigate the possible participation of superoxide anion in the intestinal tryptophan 2,3-dioxygenase reaction.
貯存： 儲存溫度 2-8°C
生化和生理學(xué)機理： 催化超氧化物自由基的歧化反應(yīng)生成過氧化氫和氧分子。在細(xì)胞防御氧自由基的毒性作用方面發(fā)揮著重要作用。與一氧化氮 (NO) 競爭超氧化物陰離子（可與 NO 反應(yīng)形成過亞硝酸鹽），因此 SOD 能促進(jìn) NO 的活性。在培養(yǎng)的大鼠卵泡、神經(jīng)細(xì)胞系和轉(zhuǎn)基因小鼠中，SOD 也表現(xiàn)出抑制細(xì)胞凋亡的作用。
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