度他雄胺，≥99％
Product Name： Dutasteride
CAS號(hào):164656-23-9
分子量:528.53
貯存： 儲(chǔ)存溫度-20°C
可溶性： 25°C： DMSO 62 mg/mL; Water <1 mg/mL; Ethanol 6 mg/mL
生化和生理學(xué)機(jī)理：
Description：
IC50 Value： N/A
Dutasteride(GG745) is a potent inhibitor of both 5alpha-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT.
in vitro： Dutasteride inhibited (3)H-T conversion to (3)H-DHT and, as anticipated, inhibited T-induced secretion of PSA and proliferation. However the drug also inhibited DHT-induced PSA secretion and cell proliferation (IC(50) approximately 1 microM). Dutasteride competed for binding the LNCaP cell AR with an IC(50) approximately 1.5 microM. High concentrations of dutasteride (10-50 microM), but not finasteride, in steroid-free medium, resulted in enhanced cell death, possibly by apoptosis [1]. Dutasteride reduces cell viability and cell proliferation in both cell lines tested (androgen-responsive (LNCaP) and androgen-unresponsive (DU145) human prostate cancer (PCa)) [2].
in vivo： GG745 has a terminal half-life of approximately 240 h
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