VIP(pr)X-08066
Product Name： VIP(pr)X-08066
CAS號:866206-54-4
分子式:C19H17ClFN5S
分子量:401.89
貯存： 儲存溫度-20°C
可溶性： DMSO
生化和生理學(xué)機(jī)理：
VIP(pr)X-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR) antagonist that causes selective vasodilation of pulmonary arteries. VIP(pr)X-08066 significantly reduced peak PA pressure at 50 and 100 mg/kg (P < 0.05 and < 0.01, respectively) compared with MCT control animals. The 5-HT2BR antagonist VIP(pr)X-08066 significantly attenuated the elevation in PA pressure and RV hypertrophy and maintained cardiac function. VIP(pr)X-08066 prevents the severity of PAH in the MCT rat model.
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