產(chǎn)品名稱：Abacavir 5’-β-D-Glucuronide Sodium Salt
產(chǎn)品CAS：
規(guī)格含量：2mg
產(chǎn)品價格：面議
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產(chǎn)品詳細介紹
標(biāo)準(zhǔn)品編號:
A104985
名稱:
Abacavir 5’-β-D-Glucuronide Sodium Salt
別名:
[(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl-β-D-Glucopyranosiduronic Acid Sodium Salt; Abacavir 5’-Glucuronide Sodium Salt
備用CAS:
384329-76-4 free acid
分子式:
C??H??N?NaO?
狀態(tài)：
Pale Beige Solid
熔點：
>206°C (dec.)
分子量:
484.44
儲存：
Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解性:
Methanol (Slightly), Water (Slightly)
穩(wěn)定性:
Hygroscopic
類別:
Standards; Enzyme Activators and Inhibitors;
應(yīng)用:
Abacavir 5’-β-D-Glucuronide is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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