(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Sulfate; Ziagen; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Intermediates
雜質(zhì):
Abacavir - In House Impurity
CAS號(hào):
188062-50-2
備用CAS:
free base: 136470-78-5
分子式:
C??H??N??O?S
狀態(tài)：
白色至白色固體
熔點(diǎn)：
>205°C (dec.)
分子量:
670.74
儲(chǔ)存：
-20°C Freezer, Under inert atmosphere
溶解性:
Methanol (Slightly), Water (Slightly)
類別:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
應(yīng)用:
Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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